In 2007, Khan replaced Amitabh Bachchan as the host of the third series of the popular game show Kaun Banega Crorepati, the Indian version of Who Wants to Be a Millionaire?.
The previous had hosted the show for five years from 2000-05. On January 22, 2007, Kaun Banega Crorepati aired with Khan as the new host and later ended on April 19, 2007.
On April 25, 2008, Khan began hosting the game show Kya Aap Paanchvi Pass Se Tez Hain?, the Indian version of Are You Smarter Than a 5th Grader?